全部产品分类
品牌 |
Leading Biology | 货号 |
APR00421G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRIB1 Antibody.
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分子量 |
41009 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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靶点 |
TRIB1
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.
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总结 |
TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1
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形式 |
In PBS with 0.09% (W/V) sodium azide
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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图像 |
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说明书 |
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数量 |
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