全部产品分类
品牌 |
Leading Biology | 货号 |
APR00285G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TNF-R1 Antibody.
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分子量 |
50495 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single- pass type I membrane protein Secreted. Note=A secreted form is produced through proteolytic processing
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
TNF-RI
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亚型 |
Rabbit IgG
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通用名 |
TNFAR, TNFR1
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基因ID |
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UniProt ID |
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功能 |
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
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总结 |
Tumor Necrosis Factor receptor type I (TNF-RI) is also referred as p60. The p60 form of the receptor is primarily expressed on epithelial cells. Recombinant Human soluble TNF receptor Type I (sTNF-RI) is a 18.3 kDa protein containing 162 amino acid residues comprising the extra cellular domain of TNF Receptor Type I.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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说明书 |
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数量 |
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