全部产品分类
品牌 |
Leading Biology | 货号 |
APR00216G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SMC4/CAPC Antibody.
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分子量 |
147182 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
SMC4
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亚型 |
Rabbit IgG
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通用名 |
CAPC, SMC4L1
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基因ID |
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UniProt ID |
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功能 |
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
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总结 |
The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated hCAP and Bamacan), and SMC2 (also designated hCAP-E for chromosome-associated polypeptide E) with hCAP-C. The SMC2/hCAP-C complex is required for mitotic chromosome condensation and functions independently of the SMC1/SMC3 complex during the cell cycle. Both SMC2 and hCAP-C are expressed throughout the cell cycle in a variety of cell lines, including HeLa cells, Daudi B cells, Jurkat T cells, SK2 neuronal cells, and HepG2 liver cells.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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说明书 |
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数量 |
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