全部产品分类
品牌 |
Leading Biology | 货号 |
APR00157G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Beclin 1 Antibody.
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分子量 |
51589 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity) Expressed in dendrites and cell bodies of cerebellar Purkinje cells.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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靶点 |
Beclin 1
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亚型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693). Required for the abcission step in cytokinesis. May play a role in antiviral host defense (By similarity).
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总结 |
Beclin is a Bcl-2 binding protein. Its structure includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since over expression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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图像 |
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说明书 |
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数量 |
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