全部产品分类
品牌 |
Leading Biology | 货号 |
APR00146G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HDAC2 Antibody.
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分子量 |
55364 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat, Hamster, Chicken, Dog
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靶点 |
HDAC2
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亚型 |
Rabbit IgG
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基因ID |
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UniProt ID |
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功能 |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
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总结 |
HDAC2 is a class I mammalian histone deacetylase containing 488 amino acid residues with an apparent size of ~55 kDa by denaturing SDS-PAGE. HDAC2 has been shown to interact directly with transcription repressor complexes and the nuclear receptor corepressor N-CoR.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, ICC
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说明书 |
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数量 |
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