全部产品分类
品牌 |
Leading Biology | 货号 |
APR04502G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HAVCR2 Antibody (Center).
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分子量 |
33394 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
167-194 aa
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靶点 |
This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.
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亚型 |
Rabbit Ig
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通用名 |
TIM3, TIMD3
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基因ID |
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UniProt ID |
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功能 |
Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
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总结 |
CD4 (MIM 186940)-positive T helper lymphocytes can bedivided into types 1 (Th1) and 2 (Th2) on the basis of theircytokine secretion patterns. Th1 cells and their associatedcytokines are involved in cell-mediated immunity to intracellularpathogens and delayed-type hypersensitivity reactions, whereas Th2cells are involved in the control of extracellular helminthicinfections and the promotion of atopic and allergic diseases. The 2types of cells also cross-regulate the functions of the other. TIM3is a Th1-specific cell surface protein that regulates macrophageactivation and enhances the severity of experimental autoimmuneencephalomyelitis in mice.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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