全部产品分类
品牌 |
Leading Biology | 货号 |
APR06153G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TOP2A Antibody (C-term).
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分子量 |
174385 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
1167-1196 aa
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靶点 |
This TOP2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1167-1196 amino acids from the C-terminal region of human TOP2A.
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亚型 |
Rabbit Ig
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通用名 |
TOP2
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基因ID |
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UniProt ID |
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功能 |
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
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总结 |
TOP2A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:50~100
IF~~1:10~50
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图像 |
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说明书 |
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数量 |
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