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FKBP1A Antibody (C-term)

APR06008G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR06008G		100 μl / ￥4950

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FKBP1A Antibody (C-term)

品牌	Leading Biology	货号	APR06008G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FKBP1A Antibody (C-term).
分子量	11951 Da
细胞定位	Antigen Cellular Localization: Cytoplasm.
宿主	Rabbit
种属反应性	Human
免疫原	55-83 aa
靶点	This FKBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the C-terminal region of human FKBP1A.
亚型	Rabbit Ig
通用名	FKBP1, FKBP12
基因ID	2280
UniProt ID	P62942
功能	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
总结	FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, FC, E
稀释方法	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50
图像	Western blot analysis of FKBP1A antibody (C-term) (Cat. APR06008G) in Jurkat cell line lysates (35ug/lane). FKBP1A (arrow) was detected using the purified Pab. FKBP1A Antibody (C-term) (Cat. APR06008G) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FKBP1A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of FKBP1A (arrow) using rabbit polyclonal FKBP1A Antibody (C-term) (Cat. APR06008G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FKBP1A gene.
说明书	Product Datasheet Protocol
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