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MOBKL1B Antibody (C-term)

APR05900G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR05900G		100 μl / ￥4950

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MOBKL1B Antibody (C-term)

品牌	Leading Biology	货号	APR05900G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MOBKL1B Antibody (C-term).
分子量	25080 Da
宿主	Rabbit
种属反应性	Human
免疫原	188-216 aa
靶点	This MOBKL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the C-terminal region of human MOBKL1B.
亚型	Rabbit Ig
通用名	C2orf6, MOB4B, MOBK1B, MOBKL1B
基因ID	55233
UniProt ID	Q9H8S9
功能	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
总结	MOBKL1B stimulates the kinase activity of STK38 and STK38L.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, FC, E
稀释方法	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50
图像	Western blot analysis of MOBKL1B antibody (C-term) (Cat. APR05900G) in A2058 cell line lysates (35ug/lane). MOBKL1B (arrow) was detected using the purified Pab. MOBKL1B Antibody (C-term) (Cat. APR05900G) IHC analysis in formalin fixed and paraffin embedded human Prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MOBKL1B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of MOBKL1B (arrow) using rabbit polyclonal MOBKL1B Antibody (C-term) (Cat. APR05900G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MOBKL1B gene.
说明书	Product Datasheet Protocol
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