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ICOS Antibody (C-term)

APR05699G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR05699G		100 μl / ￥4950

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安诺伦（北京）生物科技有限公司

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ICOS Antibody (C-term)

品牌	Leading Biology	货号	APR05699G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ICOS Antibody (C-term).
分子量	22625 Da
细胞定位	Antigen Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein
宿主	Rabbit
种属反应性	Human
免疫原	156-185 aa
靶点	This ICOS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the C-terminal region of human ICOS.
亚型	Rabbit Ig
通用名	AILIM
基因ID	29851
UniProt ID	Q9Y6W8
功能	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
总结	ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	IHC-P, WB, FC, E
稀释方法	IHC-P~~1:50~100 WB~~1:1000 FC~~1:10~50
图像	Formalin-fixed and paraffin-embedded human lymph with ICOS Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. ICOS-S171 (Cat. APR05699G) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ICOS antibody detected the ICOS protein (arrow). ICOS Antibody (C-term) (Cat. APR05699G) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
说明书	Product Datasheet Protocol
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