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DHX58 Antibody (N-term)

APR05647G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR05647G		100 μl / ￥4950

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DHX58 Antibody (N-term)

品牌	Leading Biology	货号	APR05647G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DHX58 Antibody (N-term).
分子量	76613 Da
细胞定位	Antigen Cellular Localization: Cytoplasm.
宿主	Rabbit
种属反应性	Human
免疫原	41-69 aa
靶点	This DHX58 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human DHX58.
亚型	Rabbit Ig
通用名	D11LGP2E, LGP2
基因ID	79132
UniProt ID	Q96C10
功能	Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, E
稀释方法	WB~~1:1000 IHC-P~~1:50~100
图像	DHX58 Antibody (N-term)(Cat. APR05647G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the DHX58 antibody detected the DHX58 protein (arrow). DHX58 Antibody (N-term) (Cat. APR05647G) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DHX58 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
说明书	Product Datasheet Protocol
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