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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > PYHIN1 Antibody (N-term)

PYHIN1 Antibody (N-term)

货号 货期 规格 / 价格 询价
APR05643G 100 μl / ¥4950

PYHIN1 Antibody (N-term)

品牌

Leading Biology

货号

APR05643G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PYHIN1 Antibody (N-term).

分子量

55065 Da

细胞定位

Antigen Cellular Localization: Isoform 1: Nucleus, nucleoplasm. Isoform 5: Nucleus. Nucleus speckle.

宿主

Rabbit

种属反应性

Human

免疫原

26-55 aa

靶点

This PYHIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PYHIN1.

亚型

Rabbit Ig

通用名

IFIX

基因ID

UniProt ID

功能

Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.

总结

PYHIN1 belongs to the HIN200 family ofinterferon-inducible proteins that share a 200-amino acid signaturemotif at their C-terminal ends. HIN200 proteins are primarilynuclear and are involved in transcriptional regulation of genesimportant for cell cycle control, differentiation, and apoptosis(Ding et al., 2006 [PubMed 16479015]).

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC-P, FC, E

稀释方法

WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50

图像

PYHIN1 Antibody (N-term)(Cat. APR05643G) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the PYHIN1 antibody detected the PYHIN1 protein (arrow).

PYHIN1 Antibody (N-term) (Cat. APR05643G) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PYHIN1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

PYHIN1 Antibody (N-term) (Cat. APR05643G) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

说明书

数量

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