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品牌 |
Leading Biology | 货号 |
APR05061G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NANOS2 Antibody (C-term).
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分子量 |
15132 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
108-137 aa
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靶点 |
This NANOS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-137 amino acids from the C-terminal region of human NANOS2.
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亚型 |
Rabbit Ig
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通用名 |
NOS2
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基因ID |
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UniProt ID |
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功能 |
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).
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总结 |
NANOS2 is required to support proliferation and self-renewal of proximal germ cells in males only. It probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. It is essential for spermatogonia formation.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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图像 |
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说明书 |
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数量 |
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