全部产品分类
品牌 |
Leading Biology | 货号 |
APR04528G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UBR1 Antibody (N-term).
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分子量 |
200211 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol
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宿主 |
Rabbit
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种属反应性 |
Mouse
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免疫原 |
245-274 aa
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靶点 |
This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
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总结 |
The N-end rule pathway is one proteolytic pathway of theubiquitin system. The recognition component of this pathway,encoded by this gene, binds to a destabilizing N-terminal residueof a substrate protein and participates in the formation of asubstrate-linked multiubiquitin chain. This leads to the eventualdegradation of the substrate protein. The protein described in thisrecord has a RING-type zinc finger and a UBR-type zinc finger.Mutations in this gene have been associated with Johanson-Blizzardsyndrome.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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