全部产品分类
品牌 |
Leading Biology | 货号 |
APR04489G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality USP14 Antibody (C-term).
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分子量 |
56069 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
355-383 aa
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靶点 |
This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.
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亚型 |
Rabbit Ig
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通用名 |
TGT
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基因ID |
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UniProt ID |
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功能 |
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
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总结 |
This gene encodes a member of the ubiquitin-specificprocessing (UBP) family of proteases that is a deubiquitinatingenzyme (DUB) with His and Cys domains. This protein is located inthe cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fusedprecursors and ubiquitinylated proteins. Mice with a mutation thatresults in reduced expression of the ortholog of this protein areretarded for growth, develop severe tremors by 2 to 3 weeks of agefollowed by hindlimb paralysis and death by 6 to 10 weeks of age.Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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