全部产品分类
品牌 |
Leading Biology | 货号 |
APR04381G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SPAM1 Antibody (C-term).
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分子量 |
57848 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Lipid-anchor, GPI-anchor.
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
429-457 aa
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靶点 |
This SPAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-457 amino acids from the C-terminal region of human SPAM1.
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亚型 |
Rabbit Ig
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通用名 |
HYAL3, PH20
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基因ID |
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UniProt ID |
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功能 |
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
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总结 |
Hyaluronidase degrades hyaluronic acid, a major structuralproteoglycan found in extracellular matrices and basementmembranes. Six members of the hyaluronidase family are clusteredinto two tightly linked groups on chromosome 3p21.3 and 7q31.3.This gene was previously referred to as HYAL1 and HYA1 and hassince been assigned the official symbol SPAM1; another familymember on chromosome 3p21.3 has been assigned HYAL1. This geneencodes a GPI-anchored enzyme located on the human sperm surfaceand inner acrosomal membrane. This multifunctional protein is ahyaluronidase that enables sperm to penetrate through thehyaluronic acid-rich cumulus cell layer surrounding the oocyte, areceptor that plays a role in hyaluronic acid induced cellsignaling, and a receptor that is involved in sperm-zona pellucidaadhesion. Abnormal expression of this gene in tumors has implicatedthis protein in degradation of basement membranes leading to tumorinvasion and metastasis. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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