全部产品分类
品牌 |
Leading Biology | 货号 |
APR04355G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CLEC6A Antibody (C-term).
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分子量 |
23998 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type II membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
137-163 aa
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靶点 |
This CLEC6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-163 amino acids from the C-terminal region of human CLEC6A.
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亚型 |
Rabbit Ig
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通用名 |
CLECSF10, DECTIN2
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基因ID |
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UniProt ID |
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功能 |
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity).
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总结 |
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2,is a type II membrane receptor with an extracellular C-typelectin-like domain fold. However, unlike dectin-1, dectin-2 lacksan immunoreceptor tyrosine-based activation motif (ITAM) in itscytoplasmic domain (Kanazawa et al., 2004 [PubMed15175046]).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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