全部产品分类
品牌 |
Leading Biology | 货号 |
APR04298G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZFP57 Antibody (Center).
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分子量 |
51919 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
269-296 aa
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靶点 |
This ZFP57 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-296 amino acids from the Central region of human ZFP57.
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亚型 |
Rabbit Ig
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通用名 |
C6orf40, ZNF698
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基因ID |
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UniProt ID |
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功能 |
Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.
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总结 |
The protein encoded by this gene is a zinc finger proteincontaining a KRAB domain. Studies in mouse suggest that thisprotein may function as a transcriptional repressor. Mutations inthis gene have been associated with transient neonatal diabetesmellitus type 1 (TNDM1).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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