全部产品分类
品牌 |
Leading Biology | 货号 |
APR04256G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RASSF1 Antibody (Center).
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分子量 |
39219 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells Colocalizes with MDM2 in the nucleus
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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免疫原 |
103-132 aa
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靶点 |
This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
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总结 |
This gene encodes a protein similar to the RAS effectorproteins. Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, whichsuggests the tumor suppressor function of this gene. Theinactivation of this gene was found to be correlated with thehypermethylation of its CpG-island promoter region. The encodedprotein was found to interact with DNA repair protein XPA. Theprotein was also shown to inhibit the accumulation of cyclin D1,and thus induce cell cycle arrest. Seven alternatively splicedtranscript variants of this gene encoding distinct isoforms havebeen reported.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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