全部产品分类
品牌 |
Leading Biology | 货号 |
APR04206G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MARCH9 Antibody (C-term).
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分子量 |
37772 Da
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细胞定位 |
Antigen Cellular Localization:
Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
304-330 aa
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靶点 |
This MARCH9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-330 amino acids from the C-terminal region of human MARCH9.
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亚型 |
Rabbit Ig
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通用名 |
RNF179
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基因ID |
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UniProt ID |
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功能 |
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
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总结 |
MARCH9 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their vesicular transport between membrane compartments.MARCH9 induces internalization of several membrane glycoproteinsand directs them to the endosomal compartment (Bartee et al., 2004[PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[suppliedby OMIM].
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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