全部产品分类
品牌 |
Leading Biology | 货号 |
APR04197G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZP3 Antibody (C-term).
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分子量 |
47018 Da
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细胞定位 |
Antigen Cellular Localization:
Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
353-380 aa
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靶点 |
This ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.
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亚型 |
Rabbit Ig
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通用名 |
ZP3A, ZP3B, ZPC
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基因ID |
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UniProt ID |
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功能 |
The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
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总结 |
The zona pellucida is an extracellular matrix thatsurrounds the oocyte and early embryo. It is composed primarily ofthree or four glycoproteins with various functions duringfertilization and preimplantation development. The protein encodedby this gene is a structural component of the zona pellucida andfunctions in primary binding and induction of the sperm acrosomereaction. The nascent protein contains a N-terminal signal peptidesequence, a conserved ZP domain, a C-terminal consensus furincleavage site, and a transmembrane domain. It is hypothesized thatfurin cleavage results in release of the mature protein from theplasma membrane for subsequent incorporation into the zonapellucida matrix. However, the requirement for furin cleavage inthis process remains controversial based on mouse studies. Avariation in the last exon of this gene has previously served asthe basis for an additional ZP3 locus; however, sequence andliterature review reveals that there is only one full-length ZP3locus in the human genome. Another locus encoding a bipartitetranscript designated POMZP3 contains a duplication of the lastfour exons of ZP3, including the above described variation, andmaps closely to this gene.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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