全部产品分类
品牌 |
Leading Biology | 货号 |
APR04164G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CSRP3 Antibody (Center).
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分子量 |
20969 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity) {ECO:0000250, ECO:0000305}
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
91-119 aa
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靶点 |
This CSRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human CSRP3.
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亚型 |
Rabbit Ig
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通用名 |
CLP, MLP
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基因ID |
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UniProt ID |
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功能 |
Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).
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总结 |
This gene encodes a member of the CSRP family of LIMdomain proteins, which may be involved in regulatory processesimportant for development and cellular differentiation. TheLIM/double zinc-finger motif found in this protein is found in agroup of proteins with critical functions in gene regulation, cellgrowth, and somatic differentiation. Mutations in this gene arethought to cause heritable forms of hypertrophic cardiomyopathy(HCM) and dilated cardiomyopathy (DCM) in humans. Alternativelyspliced transcript variants with different 5' UTR, but encoding thesame protein, have been found for this gene.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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