全部产品分类
品牌 |
Leading Biology | 货号 |
APR04118G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ATF3 Antibody (C-term).
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分子量 |
20576 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:12034827}
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
140-168 aa
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靶点 |
This ATF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the C-terminal region of human ATF3.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
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总结 |
Activating transcription factor 3 is a member of themammalian activation transcription factor/cAMP responsiveelement-binding (CREB) protein family of transcription factors.Multiple transcript variants encoding two different isoforms havebeen found for this gene. The longer isoform represses rather thanactivates transcription from promoters with ATF binding elements.The shorter isoform (deltaZip2) lacks the leucine zipperprotein-dimerization motif and does not bind to DNA, and itstimulates transcription presumably by sequestering inhibitoryco-factors away from the promoter. It is possible that alternativesplicing of the ATF3 gene may be physiologically important in theregulation of target genes.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, FC, E
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稀释方法 |
WB~~1:1000
FC~~1:10~50
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图像 |
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说明书 |
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数量 |
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