全部产品分类
品牌 |
Leading Biology | 货号 |
APR04101G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality YTHD2 Antibody (C-term).
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分子量 |
62334 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, P-body
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
551-579 aa
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靶点 |
This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.
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亚型 |
Rabbit Ig
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通用名 |
HGRG8
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基因ID |
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UniProt ID |
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功能 |
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.
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总结 |
YTHDF2 is a member of the YTH (YT521-B homology)superfamily containing YTH domain. The YTH domain is typical forthe eukaryotes and is particularly abundant in plants. The YTHdomain is usually located in the middle of the protein sequence andmay function in binding to RNA. In addition to a YTH domain, thisprotein has a proline rich region which may be involved in signaltransduction. An Alu-rich domain has been identified in one of theintrons of this gene, which is thought to be associated with humanlongevity. In addition, reciprocal translocations between this geneand the Runx1 (AML1) gene on chromosme 21 has been observed inpatients with acute myeloid leukemia. This gene was initiallymapped to chromosome 14, which was later turned out to be apseudogene.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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