全部产品分类
品牌 |
Leading Biology | 货号 |
APR04078G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDKN2B Antibody (C-term).
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分子量 |
14722 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Note=Also found in the nucleus
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
110-138 aa
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靶点 |
This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 amino acids from the C-terminal region of human CDKN2B.
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亚型 |
Rabbit Ig
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通用名 |
MTS2
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基因ID |
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UniProt ID |
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功能 |
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
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总结 |
This gene lies adjacent to the tumor suppressor geneCDKN2A in a region that is frequently mutated and deleted in a widevariety of tumors. This gene encodes a cyclin-dependent kinaseinhibitor, which forms a complex with CDK4 or CDK6, and preventsthe activation of the CDK kinases, thus the encoded proteinfunctions as a cell growth regulator that controls cell cycle G1progression. The expression of this gene was found to bedramatically induced by TGF beta, which suggested its role in theTGF beta induced growth inhibition. Two alternatively splicedtranscript variants of this gene, which encode distinct proteins,have been reported.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF, E
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稀释方法 |
WB~~1:1000
IF~~1:10~50
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图像 |
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说明书 |
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数量 |
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