全部产品分类
品牌 |
Leading Biology | 货号 |
APR03977G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MEOX1 Antibody (Center).
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分子量 |
27997 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
136-165 aa
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靶点 |
This MEOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human MEOX1.
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亚型 |
Rabbit Ig
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通用名 |
MOX1
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基因ID |
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UniProt ID |
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功能 |
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
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总结 |
This gene encodes a member of a subfamily ofnon-clustered, diverged, antennapedia-like homeobox-containinggenes. The encoded protein may play a role in the molecularsignaling network regulating somite development. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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图像 |
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说明书 |
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数量 |
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