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RIPK3 Antibody (C-term)

APR03974G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR03974G		100 μl / ￥4950

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RIPK3 Antibody (C-term)

品牌	Leading Biology	货号	APR03974G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RIPK3 Antibody (C-term).
分子量	56887 Da
细胞定位	Antigen Cellular Localization: Cytoplasm, cytosol. Cell membrane Mitochondrion
宿主	Rabbit
种属反应性	Human
免疫原	480-509 aa
靶点	This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of human RIPK3.
亚型	Rabbit Ig
通用名	RIP3
基因ID	11035
UniProt ID	Q9Y572
功能	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
总结	The product of this gene is a member of thereceptor-interacting protein (RIP) family of serine/threonineprotein kinases, and contains a C-terminal domain unique from otherRIP family members. The encoded protein is predominantly localizedto the cytoplasm, and can undergo nucleocytoplasmic shuttlingdependent on novel nuclear localization and export signals. It is acomponent of the tumor necrosis factor (TNF) receptor-I signalingcomplex, and can induce apoptosis and weakly activate the NF-kappaBtranscription factor.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, E
稀释方法	WB~~1:1000 IHC-P~~1:10~50
图像	Anti-RIPK3 Antibody (C-term) at 1:500 dilution + HT-29 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 57 kDa Blocking/Dilution buffer: 5% NFDM/TBST. RIPK3 Antibody (C-term) (Cat. APR03974G) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the RIPK3 antibody detected the RIPK3 protein (arrow). RIPK3 Antibody (C-term) (APR03974G)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RIPK3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
说明书	Product Datasheet Protocol
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