全部产品分类
品牌 |
Leading Biology | 货号 |
APR03915G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Mouse Mst1r Antibody (C-term).
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分子量 |
150519 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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种属反应性 |
Mouse
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免疫原 |
1013-1041 aa
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靶点 |
This Mouse Mst1r antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1013-1041 amino acids from the C-terminal region of mouse Mst1r.
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亚型 |
Rabbit Ig
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通用名 |
Ron, Stk
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基因ID |
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UniProt ID |
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功能 |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
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总结 |
Receptor for macrophage stimulating protein (MSP). Has a tyrosine-protein kinase activity.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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图像 |
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说明书 |
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数量 |
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