全部产品分类
品牌 |
Leading Biology | 货号 |
APR03910G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KLKB1 Antibody (C-term).
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分子量 |
71370 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
508-537 aa
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靶点 |
This KLKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 amino acids from the C-terminal region of human KLKB1.
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亚型 |
Rabbit Ig
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通用名 |
KLK3
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基因ID |
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UniProt ID |
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功能 |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
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总结 |
Plasma prekallikrein is a glycoprotein that participatesin the surface-dependent activation of blood coagulation,fibrinolysis, kinin generation and inflammation. It is synthesizedin the liver and secreted into the blood as a single polypeptidechain. Plasma prekallikrein is converted to plasma kallikrein byfactor XIIa by the cleavage of an internal Arg-Ile bond. Plasmakallikrein therefore is composed of a heavy chain and a light chainheld together by a disulphide bond. The heavy chain originatesfrom the amino-terminal end of the zymogen and contains 4 tandemrepeats of 90 or 91 amino acids. Each repeat harbors a novelstructure called the apple domain. The heavy chain is required forthe surface-dependent pro-coagulant activity of plasma kallikrein.The light chain contains the active site or catalytic domain of theenzyme and is homologous to the trypsin family of serine proteases.Plasma prekallikrein deficiency causes a prolonged activatedpartial thromboplastin time in patients.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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