全部产品分类
品牌 |
Leading Biology | 货号 |
APR03899G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RBBP8 Antibody (C-term).
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分子量 |
101942 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
763-792 aa
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靶点 |
This RBBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-792 amino acids from the C-terminal region of human RBBP8.
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亚型 |
Rabbit Ig
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通用名 |
CTIP
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基因ID |
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UniProt ID |
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功能 |
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.
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总结 |
The protein encoded by this gene is a ubiquitouslyexpressed nuclear protein. It is found among several proteins thatbind directly to retinoblastoma protein, which regulates cellproliferation. This protein complexes with transcriptionalco-repressor CTBP. It is also associated with BRCA1 and is thoughtto modulate the functions of BRCA1 in transcriptional regulation,DNA repair, and/or cell cycle checkpoint control. It is suggestedthat this gene may itself be a tumor suppressor acting in the samepathway as BRCA1. Three transcript variants encoding two differentisoforms have been found for this gene. More transcript variantsexist, but their full-length natures have not been determined.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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