全部产品分类
品牌 |
Leading Biology | 货号 |
APR03850G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MMP13 Antibody (Center).
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分子量 |
53820 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted, extracellular space, extracellular matrix. Secreted
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
253-282 aa
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靶点 |
This MMP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human MMP13.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
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总结 |
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. The protein encoded by this genecleaves type II collagen more efficiently than types I and III. Itmay be involved in articular cartilage turnover and cartilagepathophysiology associated with osteoarthritis. The gene is part ofa cluster of MMP genes which localize to chromosome 11q22.3.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF, IHC-P, E
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稀释方法 |
WB~~1:1000
IF~~1:10~50
IHC-P~~1:10~50
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图像 |
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说明书 |
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数量 |
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