全部产品分类
品牌 |
Leading Biology | 货号 |
APR03765G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Bak Antibody (BH3 Domain Specific).
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分子量 |
23409 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion membrane; Single-pass membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
56-91 aa
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靶点 |
This Bak antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-91 amino acids from human Bak.
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亚型 |
Rabbit Ig
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通用名 |
BAK, BCL2L7, CDN1
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基因ID |
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UniProt ID |
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功能 |
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
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总结 |
BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, WB, E
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稀释方法 |
IHC-P~~1:50~100
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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