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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > HYAL2 Antibody (Center)

HYAL2 Antibody (Center)

货号 货期 规格 / 价格 询价
APR03703G 100 μl / ¥4950

HYAL2 Antibody (Center)

品牌

Leading Biology

货号

APR03703G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HYAL2 Antibody (Center).

分子量

53860 Da

细胞定位

Antigen Cellular Localization: Cell membrane; Lipid-anchor, GPI-anchor

宿主

Rabbit

种属反应性

Human

免疫原

128-157 aa

靶点

This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human HYAL2.

亚型

Rabbit Ig

通用名

LUCA2

基因ID

UniProt ID

功能

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.

总结

This gene encodes a weak acid-active hyaluronidase. Theencoded protein is similar in structure to other more activehyaluronidases. Hyaluronidases degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan andfragments of hyaluronan are thought to be involved in cellproliferation, migration and differentiation. Although it waspreviously thought to be a lysosomal hyaluronidase that is activeat a pH below 4, the encoded protein is likely a GPI-anchored cellsurface protein. This hyaluronidase serves as a receptor for theoncogenic virus Jaagsiekte sheep retrovirus. The gene is one ofseveral related genes in a region of chromosome 3p21.3 associatedwith tumor suppression. This gene encodes two alternatively splicedtranscript variants which differ only in the 5' UTR.

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC-P, E

稀释方法

WB~~1:1000 IHC-P~~1:10~50

图像

Western blot analysis of HYAL2 Antibody (Center) Pab (Cat. APR03703G) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. HYAL2 Antibody (Center) (arrow) was detected using the purified Pab.

HYAL2 Antibody (Center) (Cat. APR03703G)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

说明书

数量

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