全部产品分类
品牌 |
Leading Biology | 货号 |
APR03618G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NOD1 Antibody (C-term).
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分子量 |
107691 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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免疫原 |
923-951 aa
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靶点 |
This NOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 923-951 amino acids from the C-terminal region of human NOD1.
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亚型 |
Rabbit Ig
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通用名 |
CARD4
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基因ID |
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UniProt ID |
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功能 |
Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
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总结 |
This gene encodes a member of the NOD (nucleotide-bindingoligomerization domain) family. This member is a cytosolic protein.It contains an N-terminal caspase recruitment domain (CARD), acentrally located nucleotide-binding domain (NBD), and 10 tandemleucine-rich repeats (LRRs) in its C terminus. The CARD is involvedin apoptotic signaling, LRRs participate in protein-proteininteractions, and mutations in the NBD may affect the process ofoligomerization and subsequent function of the LRR domain. Thisprotein is an intracellular pattern-recognition receptor (PRR) thatinitiates inflammation in response to a subset of bacteria throughthe detection of bacterial diaminopimelic acid. Multiplealternatively spliced transcript variants differring in the 5' UTRhave been described, but the full-length nature of these variantshas not been determined.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, FC, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
FC~~1:10~50
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图像 |
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说明书 |
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数量 |
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