全部产品分类
品牌 |
Leading Biology | 货号 |
APR03603G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAD17 Antibody (Center).
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分子量 |
77055 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
218-246 aa
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靶点 |
This RAD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human RAD17.
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亚型 |
Rabbit Ig
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通用名 |
R24L
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基因ID |
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UniProt ID |
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功能 |
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
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总结 |
The protein encoded by this gene is highly similar to thegene product of Schizosaccharomyces pombe rad17, a cell cyclecheckpoint gene required for cell cycle arrest and DNA damagerepair in response to DNA damage. This protein shares strongsimilarity with DNA replication factor C (RFC), and can form acomplex with RFCs. This protein binds to chromatin prior to DNAdamage and is phosphorylated by the checkpoint kinase ATR followingdamage. This protein recruits the RAD1-RAD9-HUS1 checkpoint proteincomplex onto chromatin after DNA damage, which may be required forits phosphorylation. The phosphorylation of this protein isrequired for the DNA-damage-induced cell cycle G2 arrest, and isthought to be a critical early event during checkpoint signaling inDNA-damaged cells. Eight alternatively spliced transcript variantsof this gene, which encode four distinct proteins, have beenreported. Two pseudogenes, located on chromosomes 7 and 13, havebeen identified.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, FC, E
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稀释方法 |
WB~~1:1000
FC~~1:10~50
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图像 |
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说明书 |
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数量 |
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