全部产品分类
品牌 |
Leading Biology | 货号 |
APR03591G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PLAG1 Antibody (N-term).
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分子量 |
55909 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus Note=Strong nucleolar localization when sumoylation is inhibited
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
8-35 aa
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靶点 |
This PLAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of human PLAG1.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
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总结 |
Pleomorphic adenoma gene 1 encodes a zinc finger proteinwith 2 putative nuclear localization signals. PLAG1, which isdevelopmentally regulated, has been shown to be consistentlyrearranged in pleomorphic adenomas of the salivary glands. PLAG1 isactivated by the reciprocal chromosomal translocations involving8q12 in a subset of salivary gland pleomorphic adenomas. Threetranscript variants encoding two different isoforms have been foundfor this gene.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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图像 |
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说明书 |
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数量 |
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