全部产品分类
品牌 |
Leading Biology | 货号 |
APR03554G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PSMB11 Antibody (C-term).
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分子量 |
32530 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
250-278 aa
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靶点 |
This PSMB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human PSMB11.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).
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总结 |
Proteasomes generate peptides that are presented by majorhistocompatibility complex (MHC) I molecules to other cells of theimmune system. Proteolysis is conducted by 20S proteasomes,complexes of 28 subunits arranged as a cylinder in 4heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7,and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM600306). Three additional subunits, beta-1i (PSMB9; MIM 177045),beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), areinduced by gamma-interferon (IFNG; MIM 147570) and arepreferentially incorporated into proteasomes to makeimmunoproteasomes. PSMB11, or beta-5t, is a catalytic subunitexpressed exclusively in cortical thymic epithelial cells (Murataet al., 2007 [PubMed 17540904]).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:50~100
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图像 |
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说明书 |
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数量 |
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