全部产品分类
品牌 |
Leading Biology | 货号 |
APR03506G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ANAPC5 Antibody (Center).
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分子量 |
85077 Da
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
156-185 aa
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靶点 |
This ANAPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ANAPC5.
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亚型 |
Rabbit Ig
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通用名 |
APC5
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基因ID |
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UniProt ID |
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功能 |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
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总结 |
This gene encodes a tetratricopeptide repeat-containingcomponent of the anaphase promoting complex/cyclosome (APC/C), alarge E3 ubiquitin ligase that controls cell cycle progression bytargeting a number of cell cycle regulators such as B-type cyclinsfor 26S proteasome-mediated degradation through ubiquitination. Theencoded protein is required for the proper ubiquitination functionof APC/C and for the interaction of APC/C with transcriptioncoactivators. It also interacts with polyA binding protein andrepresses internal ribosome entry site-mediated translation.Multiple transcript variants encoding different isoforms have beenfound for this gene. These differences cause translation initiationat a downstream AUG and result in a shorter protein (isoform b),compared to isoform a.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, FC, E
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稀释方法 |
WB~~1:1000
FC~~1:10~50
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图像 |
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说明书 |
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数量 |
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