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C1orf51 Antibody (N-term)

APR03438G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR03438G		100 μl / ￥4950

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C1orf51 Antibody (N-term)

品牌	Leading Biology	货号	APR03438G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality C1orf51 Antibody (N-term).
分子量	41443 Da
细胞定位	Antigen Cellular Localization: Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body.
宿主	Rabbit
种属反应性	Human
免疫原	18-47 aa
靶点	This C1orf51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human C1orf51.
亚型	Rabbit Ig
通用名	C1orf51
基因ID	148523
UniProt ID	Q8N365
功能	Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, FC, E
稀释方法	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50
图像	C1orf51 Antibody (N-term) (Cat. APR03438G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the C1orf51 antibody detected the C1orf51 protein (arrow). C1orf51 antibody (N-term) (Cat. APR03438G) immunohistochemistry analysis in formalin fixed and paraffin embedded human large intestine followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the C1orf51 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. C1orf51 Antibody (N-term) (Cat. APR03438G) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
说明书	Product Datasheet Protocol
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