全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02415G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDKN1C Antibody (Ascites).
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分子量 |
32177 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Mouse
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种属反应性 |
Human
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免疫原 |
34-64 aa
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靶点 |
This CDKN1C antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from human CDKN1C.
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克隆号 |
522CT9.5.1
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亚型 |
IgM
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通用名 |
KIP2
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基因ID |
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UniProt ID |
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功能 |
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
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总结 |
This gene is imprinted, with preferential expression ofthe maternal allele. The encoded protein is a tight-binding, stronginhibitor of several G1 cyclin/Cdk complexes and a negativeregulator of cell proliferation. Mutations in this gene areimplicated in sporadic cancers and Beckwith-Wiedemann syndorome,suggesting that this gene is a tumor suppressor candidate. Threetranscript variants encoding two different isoforms have been foundfor this gene.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:500~16000
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图像 |
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说明书 |
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数量 |
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