全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02354G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRAF2 Antibody.
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分子量 |
55859 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
This TRAF2 monoclonal antibody is generated from mouse immunized with TRAF2 recombinant protein.
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克隆号 |
214CT16.3.4
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亚型 |
IgG1,K
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通用名 |
TRAP3
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基因ID |
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UniProt ID |
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功能 |
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
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总结 |
The protein encoded by this gene is a member of the TNFreceptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from members ofthe TNF receptor superfamily. This protein directly interacts withTNF receptors, and forms a heterodimeric complex with TRAF1. Thisprotein is required for TNF-alpha-mediated activation of MAPK8/JNKand NF-kappaB. The protein complex formed by this protein and TRAF1interacts with the inhibitor-of-apoptosis proteins (IAPs), andfunctions as a mediator of the anti-apoptotic signals from TNFreceptors. The interaction of this protein with TRADD, a TNFreceptor associated apoptotic signal transducer, ensures therecruitment of IAPs for the direct inhibition of caspaseactivation. BIRC2/c-IAP1, an apoptosis inhibitor possessingubiquitin ligase activity, can unbiquitinate and induce thedegradation of this protein, and thus potentiate TNF-inducedapoptosis. Multiple alternatively spliced transcript variants havebeen found for this gene, but the biological validity of only onetranscript has been determined.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF, E
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稀释方法 |
WB~~1:100~1000
IF~~1:10~50
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图像 |
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说明书 |
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数量 |
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