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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > PRPK / TP53RK Antibody (clone 4B9-1H3)

PRPK / TP53RK Antibody (clone 4B9-1H3)

LM20854
货号 货期 规格 / 价格 询价

PRPK / TP53RK Antibody (clone 4B9-1H3)

品牌

Leading Biology

货号

LM20854

产品分类

单克隆抗体

研究领域

形式

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.

纯度

Mouse

复溶

Abe Y.,et al.J. Biol. Chem. 276:44003-44011(2001). Abe Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004). Deloukas P.,et al.Nature 414:865-871(2001). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

储存条件

Human

储存溶液

TP53-regulating kinase, 2.7.11.1, Atypical serine/threonine protein kinase TP53RK, EKC/KEOPS complex subunit TP53RK, 3.6.-.-, Nori-2, p53-related protein kinase, TP53RK, C20orf64, PRPK

应用

IHC-P (10 μg/ml)

产品描述

Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. Cellular_Location Nucleus. Tissue_Location Highly expressed in testis. Weakly expressed in heart kidney and spleen

数量

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