全部产品分类
品牌 |
Leading Biology | 货号 |
LM20853 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Store at -20°C.Stable for 12 months from date of receipt
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形式 |
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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纯度 |
Mouse |
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试剂准备 |
Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
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复溶 |
Brewis N.D.,et al.Biochim. Biophys. Acta 1171:231-233(1992).
Cohen P.T.W.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Hu M.C.-T.,et al.J. Biol. Chem. 273:33561-33565(1998).
Zhou G.,et al.J. Biol. Chem. 277:6391-6398(2002).
Mourtada-Maarabouni M.,et al.Cell Death Differ. 10:1016-1024(2003).
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储存条件 |
Human
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储存溶液 |
PP X;PP-X;PP4;PP4C;PP4C;PP4C_HUMAN;PPH3;PPP4;ppp4c;PPX;protein phosphatase 4 (formerly X), catalytic subunit;Protein phosphatase 4 catalytic subunit;Protein phosphatase X; Protein phosphatase X;protein phosphatase X, catalytic subunit;Serine/threonine protein phosphatase 4 catalytic subunit;Serine/threonine-protein phosphatase 4 catalytic subunit.
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应用 |
WB~~1:200
ICC~~1:200
IHC~~1:100
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产品描述 |
Function
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Cellular_Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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数量 |
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