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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > KPNA2 Antibody

KPNA2 Antibody

LM20539
货号 货期 规格 / 价格 询价

KPNA2 Antibody

品牌

Leading Biology

货号

LM20539

产品分类

单克隆抗体

研究领域

产品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

纯度

Mouse

复溶

1.Mod Pathol. 2014 Jan;27(1):96-106.2.PLoS One. 2013;8(3):e57911.

储存条件

Human, Mouse

储存溶液

Importin subunit alpha-1, Karyopherin subunit alpha-2, RAG cohort protein 1, SRP1-alpha, KPNA2, RCH1, SRP1

应用

E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000

产品描述

Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Cellular_Location Cytoplasm. Nucleus Tissue_Location Expressed ubiquitously.

数量

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