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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > KCNQ1 Antibody

KCNQ1 Antibody

LM20531
货号 货期 规格 / 价格 询价

KCNQ1 Antibody

品牌

Leading Biology

货号

LM20531

产品分类

单克隆抗体

研究领域

产品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

纯度

Mouse

复溶

1. Biochem Biophys Res Commun. 2009 May 29;383(2):206-9. 2. J Biol Chem. 2009 Jun 12;284(24):16452-62.

储存条件

Human

储存溶液

Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, KCNQ1, KCNA8, KCNA9, KVLQT1

应用

E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400

产品描述

Function Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Cellular_Location Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein Tissue_Location Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries

数量

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