全部产品分类
品牌 |
Leading Biology | 货号 |
LM20011 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Store at +4°C or at -20°C.
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浓度 |
Rat anti-Mouse CD104 antibody, clone 346-11A recognizes mouse integrin beta 4 (CD104), a 200 kDa glycoprotein that can associate with integrin alpha 6 (CD49f) to form a heterodimer on the cell surface. Expression of CD104 is localised to the basal region of a wide variety of epithelial cells. In mice, CD104 is also expressed on peripheral neurones, carcinoma cell lines and a subset of endothelial cells. The alpha 6 beta 4 (CD49f/CD104) integrin has been identified as a component of hemidesmosomes in stratified squamous epithelium where it plays an important role in the adhesion of epithelia to basement membrane.Studies suggest that the CD49f/CD104 integrin is involved in cell matrix adhesion but expression of the CD49f/CD104 integrin in endothelial cells is thought to have a different function. |
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纯度 |
Rat |
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复溶 |
1. Kennel, S.J. <i>et al.</i> (1992) The beta 4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice.</br>J Cell Sci. 101 ( Pt 1): 145-50. 2. Kennel, S.J. <i>et al.</i> (1989) Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily.</br>J Biol Chem. 264 (26): 15515-21. 3. Moik, D.V. <i>et al.</i> (2011) Loss of migfilin expression has no overt consequences on murine development and homeostasis.</br>J Cell Sci. 124: 414-21. 4. Lämmermann, T. <i>et al.</i> (2008) Rapid leukocyte migration by integrin-independent flowing and squeezing.</br>Nature. 453: 51-5. 5. Sonnenberg, A. <i>et al</i>. (1990) The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties.</br>J Cell Sci. 96:207-17. 6. Kennel, S.J. <i>et al</i>. (1986) Tumor antigen on benign adenomas and on murine lung carcinomas quantitated by a two-site monoclonal antibody assay.</br>Cancer Res. 46:707-12.
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储存条件 |
Mouse
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储存溶液 |
Integrin beta-4, CD104, Itgb4
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数量 |
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