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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Glutathione Peroxidase 4 Antibody (Clone 1H11)品牌 |
Leading Biology | 货号 |
AMRa00028G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Glutathione Peroxidase 4 antibody (Clone 1H11).
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分子量 |
22175 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform Mitochondrial: Mitochondrion.
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Glutathione Peroxidase 4
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克隆号 |
Clone 1H11
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亚型 |
Mouse IgG1
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基因ID |
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UniProt ID |
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功能 |
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
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总结 |
Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic /mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
E, IP
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别名 |
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, GPX4
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图像 |
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说明书 |
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数量 |
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