品牌 |
Leading Biology | 货号 |
APR14917G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Alpha II Spectrin antibody.
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分子量 |
240 KDa
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宿主 |
Mouse
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种属反应性 |
Bovine, Human, Rat
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靶点 |
Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin.
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克隆号 |
3D7
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亚型 |
IgG1
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UniProt ID |
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总结 |
The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).
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形式 |
Affinity purified from tissue culture supernatant.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF
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稀释方法 |
WB~~ 1:3000
IF~~ 1:500
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别名 |
Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit, SPTAN1, NEAS, SPTA2
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图像 |
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~240k alpha II spectrin protein.
Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and DNA (blue). |
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说明书 |
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数量 |
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