全部产品分类
品牌 |
Leading Biology | 货号 |
APR13098G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Rhodopsin antibody.
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分子量 |
39 KDa
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Purified native bovine rhodopsin.
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克隆号 |
1D4
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亚型 |
IgG1
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基因ID |
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UniProt ID |
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总结 |
Rhodopsin is a photoreceptor protein found in retinal rods. It is acomplex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsinand undergoes a series of complex reactions in response to visible light resulting in thetransmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a majorcontributor to various retinopathies such as retinitis pigmentosa. The disease-causing proteingenerally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filamentnetwork and impairs the ability of the cell to degrade non-functioning proteins which leads tophotoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linkedcongenital stationary night blindness, mainly due toconstitutive activation, when the mutationsoccur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several otherpathological states relating to rhodopsin have been discovered including poor post-Golgitrafficking, dysregulative activation, rod outer segment instability and arrestin binding.
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形式 |
Protein G purified culture supernatant.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC
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稀释方法 |
IHC~~ 1:100
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别名 |
Rhodopsin, RHO
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图像 |
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说明书 |
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数量 |
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