全部产品分类
品牌 |
Leading Biology | 货号 |
APG02396G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Caspase-7 antibody (Clone B4-G2).
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分子量 |
34277 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Caspase-7
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克隆号 |
B4-G2
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亚型 |
Mouse IgG1
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通用名 |
MCH3
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基因ID |
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UniProt ID |
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功能 |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
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总结 |
The caspase family of cysteine proteases plays a key role in apoptosis. Caspase-7, also known as Mch3α, ICE/LAP3 and CMH1, is a 34 kDa protein that is activated during Fas- and TNF-induced apoptosis. Caspase-7 has been identified as a major contributor to the execution phase of cellular apoptosis. It cleaves essential cellular machinery following its own cleavage from an inactive proenzyme to an active heterodimeric form. Caspase-7 is processed by caspase-3, -6, -8, -9, and –10 as well as by Granzyme B.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IP
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别名 |
CASP7, CASP-7, ICE-LAP3, CMH-1, MCH3, EC 3.4.22.60
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说明书 |
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数量 |
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